The SMART IRB agreement is a master`s contract for IRB reliance signed by more than a hundred academic, commercial and clinical institutions, including OHSU. Studies can use this trust agreement through three different mechanisms: the SMART IRB online reliance system, an acknowledgement letter (LOA) or the SMART IRB Reliance Exchange (IREx). The multi-site (IRB) review has increased the frequency of more than a decade ago, with an increase in trust and trust agreements that support national and regional consortia as well as disease and population-specific networks. While the growing number of agreements has been successful, they have posed considerable challenges and highlighted the potential benefits of a single national agreement. The expected changes in federal legislation have highlighted the need to systematize and simplify reliance on NI. To address these challenges, the NIH National Center for Advancing Translational Sciences has funded a project to create a national IRB Trust Network, which will support the national implementation of a single IRB review (SIRB). Launched in July 2016, the IRB “Streamlined, Multisite, Accelerated Resources for Trials” (SMART) platform was launched to facilitate the dissemination, adoption and implementation of a joint IRB trust agreement and support tools and resources. More than 580 institutions have joined SMART IRB`s Master Common Institutional Review Board Authorization Agreement and have begun using the SMART IRB platform to support sIRB agreements. Here we describe the principles of the agreement and the operational benefits and challenges of its use. The early success of SMART IRB confirms the usefulness of collaborative, flexible and centralized approaches to support the RRS review, while underscoring the need for greater national harmonization. 7 Any institution that is a legal entity under the FWA of another institution or has its own FWA or IRB organisation number must carry out its own membership agreement regardless of current or legal affiliations to other participating institutions. To begin the long process of institutional orientation, The SMART IRB team and NCATS convened the Harmonization Steering Committee (HSC), made up of a wide range of stakeholders, including representatives from NIH, OHRP, Food and Drug Administration (FDA), Veterans Affairs (VA), AAHRPP, Federal Demonstration Partnership, NCATS Trial Innovation Network and independent and institutional experts IRB and HRPP, to develop consistent strategies to demonstrate and disseminate. , processes and procedures for checking sIRB.